The day before Steve Jobs died in October, Apple, the company he co-founded, from which he was once fired and to which he returned to lead to unprecedented success, announced the latest generation of the iPhone—the iPhone 4S.

It is fitting that one of the most compelling features of the new phone is Siri, a voice-recognition application that promises to make the latest iPhone even more useful for all users, especially people with visual and other impairments.

On the Siri web site, Apple says: “Talk to Siri as you would to a person. Say something like ‘Tell my wife I’m running late.’ ‘Remind me to call the vet.’ ‘Any good burger joints around here?’ And Siri answers you. It does what you say and finds the information you need. And then it hits you. You’re actually having a conversation with your iPhone.”

That’s pretty amazing stuff. And to reinforce the potential of the application, the Siri demo video showcases a blind woman pausing while reading Braille to confirm a dinner date using Siri-enabled voice recognition.

I’ve pointed out several times on this blog (including here and here) that under Steve Jobs’ leadership Apple took great pains to ensure its products are as accessible as possible. That commitment, which is expressed very eloquently here, is making a positive impact on countless lives.

Here’s one example of that impact: Jobs’ death inspired a Wire.com writer named Tim Carmody to post a thoughtful, personal essay about how important Apple products, especially the iPod Touch, are to his four-year-old son, who has autism. In the essay, he wrote:

“It may be a stretch to say Steve Jobs invented the iPod Touch or most of the technologies contained in it. But Steve Jobs certainly put it in my son’s hands, both by making it a sub-$200 device (and in our case, giving it away free with a laptop) and by helping to create an ecosystem of software applications for people with disabilities — perhaps especially communication disabilities.”

It is still too early to know if Siri will live up to the excitement that accompanied its introduction (voice recognition software is not new, although a seamless, versatile and consistent voice-recognition interface would indeed be revolutionary). But we have reason to be confident Siri will deliver because Apple, especially in recent years, has done an excellent job delivering on its promises.

Steve Jobs will certainly be missed, but I’m confident the commitment to accessibility he instilled in his company will continue to open up the world to people with impairments – visual or otherwise.

 

 

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Christina George is a self-described “stay-at-home-mommy in New Jersey” who uses her entertaining blog and Twitter feed to chronicle life with her husband, two-year old daughter and newborn son and to share “rants, raves, thoughts & other miscellanea” on a variety of topics ranging from living in a possibly haunted house to the peculiar charms of some 80s movies.

While many of her posts are lighthearted and humorous, others are more serious, including several recent posts chronicling the terrifying experience that followed the birth of her second child.

In both her pregnancies, Christina suffered from preeclampsia, a condition that can threaten the life of both mother and child. In her second pregnancy, the preeclampsia was severe enough to warrant an immediate Cesarean section, and on August 7 of this year, Christina’s son Ryan was born prematurely, weighing just 3 pounds 13 ounces. Ryan went home after four weeks in newborn intensive care, and is doing fine.

But two days after the birth, while still in the hospital, Christina experienced something totally unexpected – the complete loss of her vision. In her words:

“In the early morning hours of August 9, 2011 – around 3 am – I was awoken by my nurse coming into the room to check my blood pressure. As I looked around I noticed that everything was a little blurry, kind of like I had something floating around in my eyes. I casually mentioned it to my nurse and then went back to sleep. A few hours later it was morning and I woke up. When I opened my eyes I was shocked and completely freaked out by what I saw – absolutely nothing.”

As you can imagine, her medical team immediately snapped into action, ordering a series of tests that included a CT scan of Christina’s head. The diagnosis, ultimately made by specialists at Wills Eye Hospital, one of the United States’ preeminent ophthalmology centers, was “bilateral serous retinal detachment due to preeclampsia.” In other words, fluid buildup caused by her preeclampsia had caused both of Christina’s retinas to detach.

Although the condition was serious and frightening, the prognosis from her doctors was reassuring.

“They seemed pretty sure my vision would get better, but couldn’t say for sure how much of an improvement I’d get or how long it would take,” she wrote. “Within the next 24 hours I did see some improvement, though my vision was still very, very poor.

Her vision did indeed continue to improve, although slowly. Five weeks after Ryan’s birth, Christina reported that, “I’m still blurry and have trouble seeing things at a distance, seeing fine details and night/lowlight vision. All I can do is hope that I will get additional improvements over the next few weeks and months.”

According to the medical literature, it is indeed likely that Christina’s vision will eventually return to normal without surgical or medical intervention. I certainly hope that is the case.

I wish Christina and her family the best, and I thank her for sharing such a compelling account of what is, thankfully, a very rare experience.

 

 

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Keep those young eyes safe this Halloween

by Dr. Ryo on October 27, 2011

Halloween is a great opportunity for kids to create great memories that will cherish for the rest of their lives—not memories that will haunt them forever, such as experiencing a serious eye injury.

There are indeed several eye-health risks associated with Halloween, but the good news is that it only takes awareness, common sense and perhaps a bit of parental invention to keep the holiday eye-safe.

Here’s a quick list of frightening things that should spook parents come October 31, and what you can do to ward them off.

  • Invisibility – Although many neighborhoods have turned trick-or-treating into an afternoon activity, many children will no doubt be heading out in their costumes after the sun has set. A child will lose an impact with an automobile every time, and these impacts can be devastating to the entire body, including the eyes.  That’s why one of the most important things parents can do on Halloween is to make sure that drivers can see our kids. This means lighting them up (have them carry a flashlight or wear a light stick) and/or making them reflective, with tape attached to their costumes or sneakers. Don’t let them be invisible out there, even if they are disguised as ghosts!
  • Temporary visual impairment caused by some masksThis describes the condition caused by ill-fitting or poorly sized masks. Not being able to see can be as dangerous as not being seen (see “Invisibility” above), but I doubt that ensuring good visibility is a particularly high priority for any mask manufacturer, and it’s not the first thing that attracts young customers to a particular mask, either. Best option: use safe face makeup (see below) in place of a mask. If you can’t do that, test how well your child can see while wearing the mask (pay special attention to peripheral vision) and apply a stern parental veto to any that significantly impede sight.
  • Non-prescription contact lenses – These are indeed very scary. The prescription contact lenses millions of us wear everyday are manufactured according to strict guidelines and fitted by trained eye-care professionals. That may not be the case with decorative lenses, which may be made by unlicensed and unregulated companies using ingredients that could be hazardous to eye health. Using poorly made lenses or not handling them properly can lead to eye infections and corneal ulcers, which can result in partial or complete blindness. Here’s an FDA advisory on decorative contact lenses with more information.
  • Unsafe face makeup – Halloween makeup is regulated as a cosmetic by the FDA, which pays particular attention to the color additives used in it. Here’s an FDA list that will tell you which color additives are approved for use on the face and, specifically, near the eyes. The makeup you are considering purchasing should have a label that lists the additives used in the product; if the product you are considering has no such label, I’d advise finding a different one. Here are more makeup safety tips from the FDA.)
  • Pointy things – Swords, knives, pitchforks, wands and other like objects can cause serious eye injuries – even if they are made out of plastic. Best option: don’t let your kids carry them while trick or treating, during which they will no doubt be waved around. They’ll fight you on that, I’m sure, after all, no would-be Captain Jack Sparrow wants to leave home without his sword. Your next-best option might to say OK, but with the mandate that all these pointy things be kept attached to a belt or in a scabbard.

Here are more tips from the Centers for Disease Prevention to help ensure your kids have a safe and enjoyable Halloween.

 

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Any visitor to San Francisco is likely to have a list of not-to-miss attractions to visit – Alcatraz, the Golden Gate Bridge and Haight Asbury come immediately to mind. And there’s one more attraction that readers of this blog may want to add to their list: The Museum of Vision, which is located in the heart of the city’s waterfront district.

The Museum of Vision is an educational program of the Foundation of the American Academy of Ophthalmology, whose mission is the preservation and promotion of ophthalmic heritage.

San Francisco is one of the world’s great cities, and a great location for the museum. But recognizing that not everyone can make it to the “city by the bay,” last year the Museum of Vision commemorated its 30th anniversary with the launch of www.museumofvision.org, a website that puts all of its exhibits – past and                                                          present –right at your fingertips.

In both its physical and online iterations, the Museum of Vision serves as a one-of-a-kind educational resource for use by ophthalmologists, medical historians, researchers and the public.

The museum’s current exhibit is “Collecting Ophthalmology: 30 Years at the Museum” and features selected items from its one-of-a-kind collection of more than 38,000 artifacts, rare books and archival materials. The collection, which dates from the third century B.C. to the present, includes the history of the American Academy of Ophthalmology, personal papers of physicians and related professionals, oral histories, surgical instruments, spectacles, coins, stamps, rare books, photographs and film.

If you are considering a visit to the physical Museum of Vision, you’ll want to stop by the visitor’s information page first, to get the details you’ll need. And, of course, you can stop by the museum’s virtual iteration anytime you want. (In both cases, admission is free!)

 

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Commemorating World Sight Day

by Dr. Ryo on October 19, 2011

Each year, thanks to the dedicated folks at VISION 2020: The Right to Sight, a global initiative for the elimination of avoidable blindness, we have the opportunity to commemorate World Sight Day, which this year was Thursday, October 13. The purpose of the commemoration is to focus global attention on blindness and vision impairment.

The facts associated with blindness and vision impairment around the world are astonishing, and can serve as a call to action for all of us. According to VISION 2020, 286 million people are visually impaired; of these, 39 million are blind and 246 million have moderate or severe visual impairment. And perhaps the most important fact is this: 90 percent of people with vision impairments live in developing countries.

Those statistics take on added meaning when we consider that 80 percent of blindness is avoidable and that blindness-prevention strategies are among the most cost-effective interventions in health care.

The VISION 2020 goal is to prevent 100 million people from becoming blind. That seems daunting, to say the least, but the organization is confident this can be accomplished by establishing sustainable, comprehensive eye-care systems as integral components of every national health system. But before that can happen, blindness and vision impairment must be perceived as global public health issues—hence the creation of World Site Day as a way of raising awareness of the issue.

You may be wondering how much difference one person can make in the quest to prevent 100 million cases of blindness. More than you might think. You can start by contacting one of the organization’s member organizations to find out what would be most helpful to them—whether that’s voluntary service, donations or some other kind of support.

I can’t think of a more important cause.

 

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Last week, while visiting my home country of Japan, I had two wonderful opportunities to share my thoughts about biotechnology, innovation and other topics, and even more important, interact with some of the country’s brightest and most inspiring individuals.

On October 4, I visited my alma mater, Keio University in Tokyo, to talk with students and teachers there about my evolution as a physician, scientist and entrepreneur and the quest to fight blinding eye diseases that is my focus, as well as the focus of my company, Acucela. It was wonderful to share my story with them, tell them about Acucela’s unique and promising approach to fighting AMD and other blinding eye diseases and answer their questions. I am always inspired and energized by these interactions and look forward to returning to the University again soon.

On the following day, I presented at the BioJapan 2011 World Business Forum in Yokohama, an event that over the course of its 25-year history has become perhaps the most important industry gathering of the year. My presentation there was designed to share my thoughts on what biotechnology leaders should consider in developing business strategies. This is very important in Japan where biotechnology is one of the few growing industries in a time of worldwide economic challenge.  The audience was extremely receptive and engaged, and I felt privileged to be in the company of so many of the country’s current and future biotech leaders.

It is always wonderful to return to Japan, and these two speaking engagements, in addition to other meetings and networking opportunities, made my most recent visit especially rewarding.

 

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One of the major themes on this blog is the absolute necessity for regular, comprehensive eye exams conducted by qualified eye care professionals. If we have those exams and also protect our eyes with the right equipment when we play sports or engage in other activities that can put them at risk, chances are very good that we will enjoy a lifetime of healthy vision.

I’ve noticed a great proliferation of online and smartphone eye tests designed for self-administration. Some of them look fairly sophisticated. But I can’t stress too strongly that they cannot serve as substitutes for comprehensive eye exams conducted by an optometrist or ophthalmologist. Think about it: even eye docs with years of experience and training don’t conduct their own eye exams (I wouldn’t even consider it!). So why would people without that training and experience trust their vision health to self-administered tests?

Having said that, I just Googled “online eye tests” and received more than 40,000 hits. And there are dozens of eye test apps available for the iPhone and iPad, and no doubt other platforms. With these online tests and apps you can, if you want, conduct your own assessments of your near and far vision, check for colorblindness and astigmatism and look for early signs of more serious conditions, including macular degeneration.

The results of some of these tests of may be fairly accurate. But, again, do you really want to entrust your vision health to someone without the proper training and experience, even if that person is you? Do you want to entrust yourself to “rule out” a serious condition that could be mitigated with early intervention?

The answer to both questions is a resounding “no.”

If for some reason you absolutely must test your own vision, please you use a resource designed and approved by ophthalmologists. One such test is available on the website of Eye Care America, the foundation of the American Academy of Ophthalmology. It requires some work to set up, but if you follow the instructions you should get results you can trust, and which you should, of course, share with your doctor at your earliest opportunity.

 

 

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My efforts as a physician and entrepreneur have the same goals: to preserve and restore the vision of people affected by blinding eye diseases. As an ophthalmologist and the founder and CEO of Acucela, I have been privileged to be able to work toward those goals every day.

But you don’t have to have gone to medical school or run a biotech company to preserve and restore vision—all you need to do is sign an organ donation card.

The lifesaving transplantation of major organs, including the heart, liver and kidney deservedly get a lot of attention, but sight-saving corneal transplants are among the most frequent human transplant procedures. According to some estimates, more than 100,000 corneal transplants take place each year, benefiting people of all ages—from infants to centenarians.

The cornea is our eyes’ main focusing element, so if it does not function properly, whether from disease, injury or infection, the impact on our sight can be very dramatic.

The good news is that corneal transplantation is a relatively simple and safe procedure with an extremely high success rate—over 90 percent. The not-so-good news is that the demand for corneas far exceeds the supply.

The most compelling case for becoming an organ donor is made by those who benefited from the generosity of others. One such person is Rita Gergely, an Iowan who underwent a successful cornea transplant in 2006 after an infection rendered her vision so bad that she could no longer drive or distinguish faces. To encourage organ donation, Rita told her story in a letter to her local newspaper: “It was easy surgery,” she wrote. “I was sedated but awake during the surgery and I was well enough to go home within a few hours. I can see to drive again which allows to me to keep working and take care of my elderly mother.”

Completing an organ donation card and making your wishes clear to your loved ones will ensure you make a positive impact on others’ lives. As Rita wrote: “People of all ages are affected by vision loss that can be restored only through a cornea transplant. You have the power to give any of these people a chance at sight.”

Several of the above links will take you to the website of the Eye Bank Association of America, which is the oldest transplant association in the United States. Since 1961, EBAA member banks have restored sight to more than 1 million individuals. If you want to learn more corneal transplantation, including how to become a donor, the organization’s site is a great place to start.

Make a difference—become an organ donor!

A corneal transplant in progress

 

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These days, most of us take for granted that we can videoconference and watch movies on our phones, obtain spoken turn-by-turn directions (in just about any language or accent we choose) from our GPS systems and answer just about any question with a simple Google query. Amazing stuff, if we stop and think about it!

Another example, but one that is more pertinent to this blog, is the ability the Internet gives all of us – even those of us who are fortunate enough to have excellent vision – to “see through the eyes” of people with vision impairments. These online vision-impairment simulators can help us better understand the struggles of our friends, loved ones and, in my case, patients.

It’s important to keep in mind that the complete absence of sight is extremely rare. According to some estimates, only about 20 percent of legally blind are totally blind, meaning they have little or no visual sensitivity to light at any level. Most have some degree of vision—albeit extremely limited. But someone with, say, glaucoma will not experience the same visual symptoms as someone with macular degeneration. With online vision simulators we no longer have to imagine what the world looks like to them; we can see for ourselves.

Here’s a roundup of several of the best vision-impairment simulators I’ve come across:

  • You can find a very technologically advanced and robust vision-impairment simulator at – where else? – visionsimulations.com. The site allows you to model just about any vision disorder you can think of, adjust the severity of the condition and even change the background and lighting conditions associated with it. Here’s just one example: you can “design” an eye floater and see how might appear to someone at the beach or indoors.
  • For more than a century, Lighthouse International has been working to meet the needs of people who are dealing with, or are at risk for, vision loss and blindness—and help people better understand those conditions. With the latter goal in mind, the organization-created site features a YouTube-based vision-impairment simulator that allows visitors to emulate five different serious eye disorders: macular degeneration, diabetic retinopathy, glaucoma, hemianopia and retinitis pigmentosa. You can use videos provided on the site or pop in the URL of any YouTube video you want to see it through the eyes of a person with those five conditions.

A screen capture from Lighthouse International’s vision-impairment simulator showing what a scene might look like to someone with glaucoma.

  • Here’s a simple but useful vision loss simulation presentation from the Arizona Center for the Blind and Visually Impaired that provides useful insights into how people with a wide variety of eye disorders see the world.
  • And the American Association for the Blind has produced a brief, fast-moving video that quickly conveys how challenging routine household tasks, such as using the phone, can be to people with several different types of eye disorders.

If you have any vision-impairment simulators to recommend, let me know and I will pass them on here on the blog.

 

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Very few aspects of warfare can be viewed as positive, either for those directly involved in the fighting or for the rest of society. But from time to time, warfare sparks beneficial innovation, and one of those developments is of particular interest to me: better protective eyewear.

Over the past ten years or we have seen the tragic toll that powerful roadside bombs and other ordnance take on our troops in Iraq, Afghanistan and elsewhere. Many of today’s injuries would have been fatal in previous wars; but, while advances in battlefield medicine have saved many lives, many of our warriors are now living with disabilities that include the loss of arms, legs and eyes.

But thankfully, advances in what’s known as “ballistic eyewear” have saved the vision of many soldiers.

Photo by mirvana

I recently came across a fascinating Military Times article that included ballistic eyewear on a list of a dozen “icons of American fighting forces that have come to symbolize true-grit ingenuity and the can-do spirit.”

“In a little more than a decade, ballistic eyewear has become an essential part of a warrior’s combat kit,” the article states. “The simple reason: The high-tech glasses are cheap—and save hundreds of American eyeballs each year.”

The article cites a 2009 article in the Journal of Trauma: Injury, Infection and Critical Care about a study that looked at more than 3,000 combat casualties. The study found the use of ballistic eye protection during current combat operations “resulted in significantly fewer and less severe ocular injuries.”

Unlike many athletes, who won’t wear eye protection unless their leagues or schools require it, today’s warriors seem to have embraced the glasses and goggles that shield their eyes. A 2009 study by the Army found that “94 percent of service members used eye protection on convoys and missions outside of forward operating bases.”

They wear eye protection because they know it works, which many service members learned first-hand: The journal study cited above found that 34 percent of service members said eye protection had saved them from an eye injury.

Eye protection was not always ubiquitous on the battlefield.

“During World War II, Korea and Vietnam, troops generally had eye protection only to help ward off environmental effects of the sun, wind and dust. Protection from flying fragments of anything from improvised explosive devices and grenades to tree bark was virtually nonexistent,” the article says. And, of course, that was also true of earlier wars, including the Civil War, which resulted in the loss of countless eyes. (I wrote about Civil War-era eye injuries here.)

Manufacturers of ballistic eyewear claim their products can prevent up to 90 percent of potential eye injuries and say they are continually incorporating suggestions from soldiers to improve them and make them more compatible with hearing protection, gas masks and night vision goggles.

At a cost of $100 or less, I can’t think of a better investment for our fighting men and women.

Several companies produce ballistic eyewear, and from what I’ve seen the competition between them appears to be rather fierce. The video below, which includes testing on a firing-range, is from one of those manufacturers. By including it, I am not endorsing one company over the others – I’m simply sharing several very effective demonstrations of the stopping-power of this type of protection.


 

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